Fig. 4

Effect of tolfenamic acid on working memory, memory recall and visual recognition deficits in ICV-OA mice. Model group mice exhibited a decrease in spontaneous alternation behaviour in Y-maze test (a), a significant decrease in 1 h and 24 h PI in novel object recognition test (b), which compared to control mice. Tolfenamic acid treatment attenuated these cognitive deficits. All results are expressed as the mean ± SEM. n = 10; ^##p < 0.01 versus control; *p < 0.05, **p < 0.01 versus model