Table 2 Genetic evidence for the biological relevance of ZIP transporters
From: Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis
| Official symbol | Protein | Mutation type | OMIM Gene locus/ phenotype | Abnormality (*Phenotypes in human) | Expression | References |
|---|---|---|---|---|---|---|
| Slc39a1 | ZIP1 | KO | 604740/ – | Abnormal embryonic development | Ubiquitous | [172] |
| Slc39a2 | ZIP2 | KO | 612166/ – | Abnormal embryonic development | Liver, ovary, skin, dendritic cell | [173] |
| Slc39a3 | ZIP3 | KO | 612168/ – | Abnormal embryonic and T-cell development | Widely distributed | [171] |
| Slc39a4 | ZIP4 | KO; *Mutation | 607059/ 201100 | Embryonic lethal, *acrodermatitis enteropathica | Small intestine | [95, 175,176,177] |
| Slc39a5 | ZIP5 | KO; *Mutation | 608730/ 615946 | Intestinal Zn excretion; Pancreatic Zn accumulation. *Nonsymptomatic high myopia | Small intestine, kidney, pancreas | [179] |
| Slc39a6 |
ZIP6 Liv1 | 608731/ – |
Abnormal gonad formation and E-cadherin expression. Glial cell migration in Drosophila | Widely distributed | [92, 146] | |
| Slc39a7 | ZIP7 Ke4 | 601416/ – |
Impaired melanin synthesis, FGFR and Notch signaling in Drosophila.
Colon epithelial cell differentiation and proliferation in mouse |
Widely distributed Colon | [180, 205, 206] | |
| Slc39a8 | ZIP 8 | KO; *Mutation | 608732/ 616721 |
Cdm mouse: Resistance to cadmium-induced testicular damage, Crohn’s disease. *Disorder of Mn transporter and glycosylation | Widely distributed | [99, 102, 182, 183] |
| Slc39a9 | ZIP9 | Expressed in breast and prostate cancer cell lines. Apoptosis regulation | Widely distributed | [184] | ||
| Slc39a10 | ZIP 10 | KO | 608733/ – |
B-cell development. Breast cancer progression |
Widely distributed. Renal cell carcinoma B-cell | [92, 147, 185, 186] |
| Slc39a13 | ZIP13 | KO *Mutation | 608735/ 612350 |
Growth retardation, abnormal hard and connective tissue development. *Spondylocheiro dysplastic Ehlers–Danlos syndrome | Hard and connective tissues | [148, 196] |
| Slc39a14 | ZIP14 | KO *Mutation | 608736/ 617013 |
Growth retardation and impaired GPCR signaling. Impaired Mn homeostasis. Adipokine production. *Childhood-onset Parkinsonism-dystonia |
Widely distributed. Bone and cartilage | [103, 187, 188] |