Table 1 Genetic evidence for the biological relevance of ZnT transporters
From: Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis
| Official symbol | Protein | Mutation type | OMIM Gene locus/ phenotype | Abnormality (*Phenotypes in human) | Expression | References |
|---|---|---|---|---|---|---|
| Slc30a1 | ZnT1 | KO | 609521/ - | Embryonic lethal | Ubiquitous | [150] |
| Slc30a2 | ZnT2 | *Mutation | 609617/ 608118 | *Low Zn in milk | Widely distributed | [151,152,153,154] |
| Slc30a3 | ZnT3 | KO | 602878/ - | Prone to seizures; similar to the synaptic and memory deficits of Alzheimer’s disease; required for pre-synaptic Erk activation and hippocampus-dependent memory | Brain | [155, 156] |
| Slc30a4 | ZnT4 | Mutation | 602095/ - | Lethal milk mutant: low Zn in milk | Ubiquitous | [157] |
| Slc30a5 | ZnT5 | KO | 607819/ - | Growth retardation, osteopenia and male-specific cardiac death; impaired mast cell functions | Ubiquitous | [158, 159] |
| Slc30a6 | ZnT6 | 611148/ - | Widely distributed | |||
| Slc30a7 | ZnT7 | KO | 611149/ - | Growth retardation, low body Zn status and low fat accumulation | Widely distributed | [160, 161] |
| Slc30a8 | ZnT8 | KO; *SNP | 611145/ 125853 | Impairment of insulin secretion and insulin-crystal formation; *type I and II diabetes mellitus | Pancreas | [162, 167] |
| Slc30a10 | ZnT10 | *Mutation | 611146/ 613280 | *Parkinsonism, hypermanganesemia, syndrome of hepatic cirrhosis, dystonia, polycythemia |
Small intestine Liver Brain | [169, 170] |